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News and Publications

Sept 22 2022

Congratulations to Amanda Bakke for successfully defending her Master's thesis!

July 28, 2022

The Kaushic Lab attends the AIDS 2022 conference in Montreal, Canada

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July 3, 2022

Congratulations to Dr. Biban Gill for being awarded the CIHR Post-doctoral Fellowship

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June 21, 2022

Congratulations to Jack Yang for successfully defending his Master's Thesis

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June 2, 2022

Congratulations to Ingrid Schwecht for winning best Undergraduate Talk at the 2022 MIRC Perey Symposium

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March 9, 2022

Congratulations to Sidney and Maddie for successfully defending!

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April 28, 2022

Congratulations to Dr. Nazli for receiving a full scholarship to attend the 24th international AIDS conference in Montreal

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September 30, 2021

Congratulations to Tushar Dhawan for sucessfully defending his Master's thesis

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March 23, 2021

Dr. Kaushic is part of a COVID-19 town hall presented by the Globe and Mail and the Royal Society of Canada

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January 7, 2021

An article on COVID-19 by Dr. Kaushic is published in the Globe and Mail 

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July 6, 2020

Dr. Kaushic publishes an article on COVID-19 immune responses

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July 6, 2020

Congratulations to Dr. Bagri for successfully defending her PhD 

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May 7, 2020

Congratulations to Ramtin Ghasemi for successfully defending his Master's thesis

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May 6, 2020

Congratulations to Haley Dupont for successfully defending her Master's thesis

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June 15, 2019

Congratulations to Ramtin for winning the John Gudson Award at the annual American Society for Reproductive Immunology Conference

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May 29, 2019

 Congratulations to Allison and Puja for winning the Outstanding Oral Presentation awards at the Faculty of Health Sciences Research Plenary

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March 15, 2019

Allison attends the 66th Annual Scientific Meeting for the Society for Reproductive Investigation (SRI) in Paris, France

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January 30, 2019

Congratulations to Jeff Lam for successfully defending his Master's thesis

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November 12, 2018

Congratulations to Allison on receiving a CIHR travel Award to present in an upcoming conference

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November 6, 2018

Congratulations to Ryan on being runner-up for the IIDR Award of Excellence undergraduate award

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November 9, 2018

Congratulations to Puja for recieving the Michael Kamin Hart Memorial scholarship

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Publications

 

2021

Felker AM, Nguyen P, Kaushic C. Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model. Viruses. 2021 Sep 25;13(10):1929. doi: 10.3390/v13101929. PMID: 34696359; PMCID: PMC8538385.

Gillgrass A, Wessels JM, Yang JX, Kaushic C. Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses. Front Immunol. 2021 Mar 5;11:617516. doi: 10.3389/fimmu.2020.617516. PMID: 33746940; PMCID: PMC7973037.

Wessels JM, Nguyen PV, Vitali D, Mueller K, Vahedi F, Felker AM, Dupont HA, Bagri P, Verschoor CP, Deshiere A, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C. Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice. Sci Rep. 2021 Feb 16;11(1):3894. doi: 10.1038/s41598-021-83242-9. PMID: 33594113; PMCID: PMC7887257.

Woods MW, Zahoor MA, Lam J, Bagri P, Dupont H, Verschoor CP, Nazli A, Kaushic C. Transcriptional response of vaginal epithelial cells to medroxyprogesterone acetate treatment results in decreased barrier integrity. J Reprod Immunol. 2021 Feb;143:103253. doi: 10.1016/j.jri.2020.103253. Epub 2020 Dec 1. PMID: 33285485.

Dhawan T, Zahoor MA, Heryani N, Workenhe ST, Nazli A, Kaushic C. TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. Viruses. 2021 Jan 6;13(1):70. doi: 10.3390/v13010070. PMID: 33419081; PMCID: PMC7825454.

2020

Bagri P, Ghasemi R, McGrath JJC, Thayaparan D, Yu E, Brooks AG, Stämpfli MR, Kaushic C. Estradiol Enhances Antiviral CD4+ Tissue-Resident Memory T Cell Responses following Mucosal Herpes Simplex Virus 2 Vaccination through an IL-17-Mediated Pathway. J Virol. 2020 Dec 9;95(1):e01206-20. doi: 10.1128/JVI.01206-20. PMID: 33028712; PMCID: PMC7737739.

Vitali D, Bagri P, Wessels JM, Arora M, Ganugula R, Parikh A, Mandur T, Felker A, Garg S, Kumar MNVR, Kaushic C. Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa. Int J Mol Sci. 2020 Jan 4;21(1):337. doi: 10.3390/ijms21010337. PMID: 31947962; PMCID: PMC6982333.

2019

Wessels JM, Lajoie J, Cooper MIJH, Omollo K, Felker AM, Vitali D, Dupont HA, Nguyen PV, Mueller K, Vahedi F, Kimani J, Oyugi J, Cheruiyot J, Mungai JN, Deshiere A, Tremblay MJ, Mazzulli T, Stearns JC, Ashkar AA, Fowke KR, Surette MG, Kaushic C. Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice. Dis Model Mech. 2019 Oct 23;12(10):dmm039669. doi: 10.1242/dmm.039669. PMID: 31537512; PMCID: PMC6826019.

Dizzell S, Nazli A, Reid G, Kaushic C. Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract. Cells. 2019 Sep 21;8(10):1120. doi: 10.3390/cells8101120. PMID: 31546582; PMCID: PMC6829272.

Nazli A, Dizzell S, Zahoor MA, Ferreira VH, Kafka J, Woods MW, Ouellet M, Ashkar AA, Tremblay MJ, Bowdish DM, Kaushic C. Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier. Cell Mol Immunol. 2019 Feb;16(2):178-194. doi: 10.1038/cmi.2017.168. Epub 2018 Mar 19. PMID: 29553138; PMCID: PMC6355787.

Anipindi VC, Bagri P, Dizzell SE, Jiménez-Saiz R, Jordana M, Snider DP, Stämpfli MR, Kaushic C. IL-17 Production by γδ+ T Cells Is Critical for Inducing Th17 Responses in the Female Genital Tract and Regulated by Estradiol and Microbiota. Immunohorizons. 2019 Jul 17;3(7):317-330. doi: 10.4049/immunohorizons.1900040. PMID: 31356161.

2018

Dupont HA, Lam J, Woods MW, Zahoor MA, Kaushic C. Hormonal influence on HIV-1 transmission in the female genital tract: New insights from systems biology. Am J Reprod Immunol. 2018 Aug;80(2):e13019. doi: 10.1111/aji.13019. Epub 2018 Jul 16. PMID: 30014538.

Wessels JM, Felker AM, Dupont HA, Kaushic C. The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women. Dis Model Mech. 2018 Aug 28;11(9):dmm035147. doi: 10.1242/dmm.035147. PMID: 30154116; PMCID: PMC6177003.

Woods MW, Zahoor MA, Dizzell S, Verschoor CP, Kaushic C. Medroxyprogesterone acetate-treated human, primary endometrial epithelial cells reveal unique gene expression signature linked to innate immunity and HIV-1 susceptibility. Am J Reprod Immunol. 2018 Jan;79(1). doi: 10.1111/aji.12781. Epub 2017 Nov 6. PMID: 29105931.

Zahoor MA, Woods MW, Dizzell S, Nazli A, Mueller KM, Nguyen PV, Verschoor CP, Kaushic C. Transcriptional profiling of primary endometrial epithelial cells following acute HIV-1 exposure reveals gene signatures related to innate immunity. Am J Reprod Immunol. 2018 Apr;79(4):e12822. doi: 10.1111/aji.12822. Epub 2018 Feb 8. PMID: 29418026.

2017

Vitali D, Wessels JM, Kaushic C. Role of sex hormones and the vaginal microbiome in susceptibility and mucosal immunity to HIV-1 in the female genital tract. AIDS Res Ther. 2017 Sep 12;14(1):39. doi: 10.1186/s12981-017-0169-4. PMID: 28893284; PMCID: PMC5594427.

Wessels JM, Lajoie J, Vitali D, Omollo K, Kimani J, Oyugi J, Cheruiyot J, Kimani M, Mungai JN, Akolo M, Stearns JC, Surette MG, Fowke KR, Kaushic C. Association of high-risk sexual behaviour with diversity of the vaginal microbiota and abundance of Lactobacillus. PLoS One. 2017 Nov 2;12(11):e0187612. doi: 10.1371/journal.pone.0187612. PMID: 29095928; PMCID: PMC5667760.

Nguyen PV, Wessels JM, Mueller K, Vahedi F, Anipindi V, Verschoor CP, Chew M, Deshiere A, Karniychuk U, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C. Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice. Sci Rep. 2017 Nov 10;7(1):15263. doi: 10.1038/s41598-017-15630-z. PMID: 29127409; PMCID: PMC5681573.

Bagri P, Anipindi VC, Nguyen PV, Vitali D, Stämpfli MR, Kaushic C. Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination. J Virol. 2017 Nov 14;91(23):e01234-17. doi: 10.1128/JVI.01234-17. PMID: 28956763; PMCID: PMC5686749.

2016

Lee Y, Dizzell SE, Leung V, Nazli A, Zahoor MA, Fichorova RN, Kaushic C. Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface. Viruses. 2016 Aug 30;8(9):241. doi: 10.3390/v8090241. PMID: 27589787; PMCID: PMC5035955.

Anipindi VC, Bagri P, Roth K, Dizzell SE, Nguyen PV, Shaler CR, Chu DK, Jiménez-Saiz R, Liang H, Swift S, Nazli A, Kafka JK, Bramson J, Xing Z, Jordana M, Wan Y, Snider DP, Stampfli MR, Kaushic C. Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. PLoS Pathog. 2016 May 5;12(5):e1005589. doi: 10.1371/journal.ppat.1005589. Erratum in: PLoS Pathog. 2016 Jun;12(6):e1005706. PMID: 27148737; PMCID: PMC4858291.

Xiu F, Anipindi VC, Nguyen PV, Boudreau J, Liang H, Wan Y, Snider DP, Kaushic C. High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells. PLoS One. 2016 Apr 11;11(4):e0153304. doi: 10.1371/journal.pone.0153304. PMID: 27064901; PMCID: PMC4827838.